Root Causes of Chronic Inflammation: What Is In Your Control
Chronic inflammation is a silent but powerful force behind many modern diseases. Unlike the temporary swelling or redness you get from an injury or infection, chronic inflammation is low-grade and long-lasting. It’s often caused by everyday choices and environments—not just your genes.
Let’s walk through the major lifestyle, environmental, and hidden medical causes of inflammation so you can better protect your health.
Lifestyle Factors That Fuel Inflammation
- What You Eat Matters: Diets high in ultra-processed foods—loaded with gut-disrupting additives, added sugars, and inflammatory fats (especially omega-6s—watch my video on which oils to avoid, like grapeseed oil, HERE)—can drive chronic inflammation. This is especially true of the Western diet, which tends to be low in fiber-rich vegetables and high in packaged foods, even so-called “healthy” ones labeled low-sugar, low-fat, or gluten/dairy-free. These patterns damage the gut microbiome and set the stage for a persistent pro-inflammatory state, especially when animal protein is consumed in excess compared to colorful anti-inflammatory vegetables.(Furman et al., 2019; Christ et al., 2019; Hennig & Deng, 2020; Ruiz-Núñez et al., 2013; Mundula et al., 2022; Chiba et al., 2019).
- Blood Sugar Spikes: Eating sugary foods and refined carbs regularly leads to spikes in blood sugar, which can promote inflammation and insulin resistance over time (Hennig & Deng, 2020; Ruiz-Núñez et al., 2013).
- Lack of Movement: Sitting too much and not getting enough physical activity are strongly linked to chronic inflammation. On the flip side, regular exercise helps calm it down (Furman et al., 2019; Christ et al., 2019; Ruiz-Núñez et al., 2013).
- Poor Sleep Habits: Not getting enough sleep or having poor sleep increases inflammation and your risk of disease (Ruiz-Núñez et al., 2013).
- Stress: Long-term stress causes hormonal changes that ramp up inflammation in your body (Bachmann et al., 2020; Furman et al., 2019; Ruiz-Núñez et al., 2013).
- Smoking and Alcohol: Tobacco and excessive alcohol are both major sources of inflammation (Ruiz-Núñez et al., 2013; Mundula et al., 2022).
Environmental Triggers of Inflammation
- Pollution: Breathing polluted air or being exposed to chemicals like PCBs and PFASs increases oxidative stress and inflammation across multiple organs (Wang et al., 2023; Hennig & Deng, 2020; Orysiak et al., 2022).
- Indoor Living: Spending too much time indoors, away from natural sunlight, increases your risk of vitamin D deficiency and inflammation. Indoor air quality and artificial light also play a role (Ruiz-Núñez et al., 2013; Mundula et al., 2022).
- Work Hazards: Jobs like firefighting, farming with pesticides and nail salons with frequent chemical use expose workers to smoke, heat, chronic stress and toxins—all of which increase inflammation (Orysiak et al., 2022).
Dental Infections and Inflammation
- Root Canals and Cavitations: Infections in root canals or areas of jawbone (cavitations) cause local inflammation that can sometimes spread systemically. These infections increase inflammatory markers like interleukins and CRP (Rocha et al., 2022; Dongari-Bagtzoglou et al., 2017; Gruber et al., 2015; Zhang et al., 2024; Krawiec et al., 2023; Monje et al., 2018; Roccuzzo et al., 2023).
- Dental Implants: If not properly maintained, dental implants can develop a condition called peri-implantitis, leading to bone loss and chronic inflammation. Some people may also react to the implant materials themselves (Suvan et al., 2023; Bellin et al., 2019).
Breast Implants, Medical Implants & Their Link to Inflammation
- Local Reactions: All breast implants cause the body to form a fibrous capsule around them. Smooth-surfaced implants usually cause milder reactions, while macrotextured or polyurethane-coated implants can lead to thicker, more inflamed capsules (Belgiovine et al., 2024; Di Pompeo et al., 2025).
- Chronic Inflammation and Systemic Symptoms: In some women, regardless of material, breast implants have been linked to chronic inflammation and symptoms like fatigue and joint pain—sometimes called Breast Implant Illness (BII). Though research is ongoing, around 50% of women report improvement after removing the implants (Hassanein et al., 2022; Tervaert et al., 2017).
- Autoimmune Reactions: Some scientists suspect that silicone and other implant materials such as titanium from metal implants can trigger immune reactions, especially in those who are genetically sensitive (Cruciani et al., 2023; Tervaert et al., 2017).
What You Can Do
Many of these sources of chronic inflammation are within your control. By choosing whole foods, staying active, managing stress, sleeping well, avoiding toxins where possible and supporting your detoxification pathways, you can protect your body from the silent damage of chronic inflammation.
Explore my Inflammation Playlist on YouTube for root-cause solutions and practical tools to reduce inflammation and feel your best!
Fullscript Supplement Resources
You can find high-quality omega-3 fatty acid supplements in my easy-to-access Dr. Patricia Approved Fullscript plan, available here:
References
- Furman D. et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019;25(12):1822–1832. https://doi.org/10.1038/s41591-019-0675-0
- Christ A. et al. Western diet and the immune system: An inflammatory connection. Immunity. 2019;51(5):794–811. https://doi.org/10.1016/j.immuni.2019.09.020
- Hennig B. & Deng P. Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks. Food Frontiers. 2020;1(1):13–14. https://doi.org/10.1002/fft2.6
- Ruiz-Núñez B. et al. Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. J Nutr Biochem. 2013;24(7):1183–1201. https://doi.org/10.1016/j.jnutbio.2013.02.009
- Mundula T. et al. Chronic systemic low-grade inflammation and modern lifestyle: the dark role of gut microbiota on related diseases with a focus on pandemic COVID-19. Curr Med Chem. 2022. https://doi.org/10.2174/0929867329666220430131018
- Chiba M. et al. Westernized diet is the most ubiquitous environmental factor in inflammatory bowel disease. Perm J. 2019;23:18-107. https://doi.org/10.7812/TPP/18-107
- Bachmann M. et al. The challenge by multiple environmental and biological factors induce inflammation in aging: their role in the promotion of chronic disease. Front Immunol. 2020;11:570083. https://doi.org/10.3389/fimmu.2020.570083
- Wang Z. et al. Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions. Environ Pollut. 2023;122756. https://doi.org/10.1016/j.envpol.2023.122756
- Orysiak J. et al. Lifestyle and environmental factors may induce airway and systemic inflammation in firefighters. Environ Sci Pollut Res Int. 2022;29(51):73741–73768. https://doi.org/10.1007/s11356-022-22479-x
- Rocha N. et al. Host-microbiome interactions regarding peri-implantitis and dental implant loss. J Transl Med. 2022;20:234. https://doi.org/10.1186/s12967-022-03636-9
- Dongari-Bagtzoglou A. et al. Clinical, immune, and microbiome traits of gingivitis and peri-implant mucositis. J Dent Res. 2017;96(1):47–55. https://doi.org/10.1177/0022034516668847
- Gruber R. et al. The pathology of bone tissue during peri-implantitis. J Dent Res. 2015;94(3):354–361. https://doi.org/10.1177/0022034514559128
- Zhang G. et al. Osteogenic microenvironment restoration around dental implants induced by an injectable MXene-based hydrogel. ACS Appl Nano Mater. 2024. https://doi.org/10.1021/acsanm.4c01511
- Krawiec K. et al. How can imbalance in oral microbiota and immune response lead to dental implant problems? Int J Mol Sci. 2023;24(17):17620. https://doi.org/10.3390/ijms242417620
- Monje A. et al. Peri-implantitis. J Clin Periodontol. 2018;45(Suppl 20):S246–S266. https://doi.org/10.1111/jcpe.12954
- Roccuzzo M. et al. Peri-implantitis as the consequence of errors in implant therapy. Periodontol 2000. 2023;91(1):159–178. https://doi.org/10.1111/prd.12482
- Suvan J. et al. Association between peri-implantitis and systemic inflammation: a systematic review. Front Immunol. 2023;14:1235155. https://doi.org/10.3389/fimmu.2023.1235155
- Bellin G. et al. Metal nanoparticles released from dental implant surfaces: potential contribution to chronic inflammation and peri-implant bone loss. Materials. 2019;12(12):2036. https://doi.org/10.3390/ma12122036
- Belgiovine C. et al. Breast implant surface topography triggers a chronic-like inflammatory response. Life Sci Alliance. 2024;7(1):e202302132. https://doi.org/10.26508/lsa.202302132
- Di Pompeo F. et al. Inflammatory response to various implant surfaces in murine models: a systematic analysis. J Plast Reconstr Aesthet Surg. 2025;103:8–17. https://doi.org/10.1016/j.bjps.2025.01.085
- Stelzel J. et al. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans. Nat Biomed Eng. 2021;5(10):1115–1130. https://doi.org/10.1038/s41551-021-00739-4
- Canese R. et al. Study of the effect of different breast implant surfaces on capsule formation and host inflammatory response in an animal model. Aesthet Surg J. 2022. https://doi.org/10.1093/asj/sjac301
- Samelko L. et al. The inflammatory effects of breast implant particulate shedding: comparison with orthopedic implants. Aesthet Surg J. 2019;39(Suppl_1):S36–S48. https://doi.org/10.1093/asj/sjy335
- Hassanein A. et al. Breast implant-associated immunological disorders. J Immunol Res. 2022;2022:8536149. https://doi.org/10.1155/2022/8536149
- Cruciani C. et al. Breast implant illness: is it causally related to breast implants? Autoimmun Rev. 2023;22(5):103448. https://doi.org/10.1016/j.autrev.2023.103448
- Beier J. et al. Effects of silicone breast implants on human cell types in vitro: a closer look on host and implant. Aesthet Plast Surg. 2022;46(5):2208–2217. https://doi.org/10.1007/s00266-021-02762-x
- Tervaert J. et al. Silicone breast implants and autoimmune rheumatic diseases: myth or reality. Curr Opin Rheumatol. 2017;29(4):348–354. https://doi.org/10.1097/BOR.0000000000000391
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