Understanding Iron Deficiency: 7 Crucial Root Causes

Understanding Iron Deficiency: 7 Crucial Root Causes

Iron deficiency is one of the most common nutrient deficiencies worldwide. It can affect anyone—children, teens, women, men, and the elderly. If you’ve ever felt unusually tired, weak, or dizzy, low iron levels might be part of the reason. But why does this happen? To better prevent and manage iron deficiency, it’s important to understand what causes it.

Root Causes of Low Iron

  1. Not Getting Enough Iron From Food
    Plant-based diets can increase the risk of low iron intake, since non-heme iron is less easily absorbed than animal-based heme iron. Even omnivores may face low iron levels due to other underlying factors.

For a deeper dive into correcting iron deficiency using nutrition and targeted supplementation, watch my Low Iron Playlist.

  1. Inflammation in the Body
    Chronic inflammation raises hepcidin levels through the impact of inflammation on the liver. An increase in hepcidin traps iron inside cells and making it harder to use for red blood cell production.
    3. Blood Loss
    Heavy menstrual periods, fibroids or digestive tract issues like ulcers can lead to iron deficiency. Women of childbearing age are especially vulnerable.
  2. Parasites
    Infections like hookworm can cause blood loss or interfere with absorption. Though less common in North America, they remain a global concern.
  3. Poor Absorption
    Conditions like celiac disease or leaky gut damage the gut lining, reducing nutrient absorption. Low stomach acid also plays a role here.Stomach acid is essential for breaking down iron into a form your body can absorb. Low stomach acid—whether from aging, stress, or infections—can impair absorption and lead to deficiency. Supporting healthy stomach acid levels through diet, stress management, and mindful eating can make a big difference. 
  1. High Iron Needs
    Growth, pregnancy, and breastfeeding increase iron requirements. Without enough intake, deficiency can develop.
  2. Gut Microbiome Dysfunction
    Your gut bacteria compete with you for iron. Imbalances in the microbiome can reduce absorption and contribute to inflammation. Your gut bacteria also influence iron absorption. Some bacteria consume iron themselves, and excess iron supplements can feed harmful strains. A balanced microbiome supports better digestion, nutrient absorption, and immune health.

Practical Takeaway

Iron deficiency isn’t just about diet—it’s a complex interplay of inflammation, absorption, stomach acid, stress, and gut health. Addressing these root causes holistically can help restore energy, balance, and resilience.

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References

Barha, C. K., et al. (2017). Sex differences in exercise efficacy to improve cognition: A systematic review and meta-analysis of randomized controlled trials in older humans. Frontiers in Neuroendocrinology, 46, 71–85. PMID: 27989771

Brown, B. M., et al. (2022). Exercise and diet in the prevention of Alzheimer’s disease: The EXERT trial. Alzheimer’s & Dementia, 18(1), 700–709. PMID: 34811847

Colcombe, S., et al. (2006). Aerobic exercise training increases brain volume in aging humans. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(11), 1166–1170. PMID: 17167157

Erickson, K. I., et al. (2011). Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America, 108(7), 3017–3022. PMID: 21282661

Liu-Ambrose, T., et al. (2010). Resistance training and executive functions: A 12-month randomized controlled trial. Archives of Internal Medicine, 170(2), 170–178. PMID: 20101006

Northey, J. M., et al. (2018). Exercise interventions for cognitive function in adults older than 50: A systematic review with meta-analysis. British Journal of Sports Medicine, 52(3), 154–160. PMID: 28438774

Voss, M. W., et al. (2011). Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience, 2, 32. PMID: 21441993

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